多くの配列バリアントがヒトの複雑な形質や疾患と関連付けられてきたが、それらの大半はノンコーディングDNA上にあるために、その生物学的機能の解明はいまだに困難である。今回我々は、SNP-SELEX（single-nucleotide polymorphism evaluation by systematic evolution of ligands ...

While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...

細胞の性分化を阻止する長鎖ノンコーディングRNAを発見 細胞内で機能を持つノンコーディングRNAを探し出す方法の開発と実践 ＜発表のポイント＞ 細胞研究は従来、DNAや酵素などのタンパク質に着目されてきたが、近年、「ジャンク」とされていた一部の ...

Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice. In the new study, published in Nature Communications, a ...

Researchers at Pohang University of Science and Technology (POSTECH) have built a platform that steers cell behavior using synthetic DNA produced inside cells, without making a single permanent change ...