In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage ...

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

As published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR ...

CRISPR-Cas9 has transformed our ability to study DNA by manipulating genomic information in a programmable fashion. The RNA-targeting CRISPR effector protein Cas13 is poised to revolutionize the study ...

CRISPR powers everything from gene editing to rapid diagnostics, but how did one of its most versatile branches arise? A new Cell study, “Functional RNA splitting drove the evolutionary emergence of ...

原核生物の防御機構CRISPR–Cas系は、汎用的なDNA編集ツールをもたらした。今回、クラス2 VI型のRNA誘導型RNA標的化CRISPR–CasエフェクターであるCas13a（以前はC2c2として知られていた）が、哺乳類細胞でのRNAのノックダウンおよび結合用に操作可能であることが ...

If CRISPR stays active too long, it could cut unintended parts of the genome. To reduce this risk, the researchers designed a self-inactivating CRISPR system. This means that CRISPR edits the gene and ...

Targeted CRISPR lipid nanoparticles eliminated 50% of tumors in mice with head and neck cancer. Researchers from Tel Aviv University (Israel), led by Razan Masarwy, have investigated utilizing CRISPR ...