ENCODE has identified 400 regions of ‘junk’ or non-coding DNA that may have a bearing on disease states, and the implications for pharma and patients are huge The announcement in September that hefty ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

From single DNA letter swaps to hidden non-coding tweaks, mutations can rewire how our bodies work—sometimes in life-changing ways. Scientists are uncovering how these changes influence protein ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

多くの配列バリアントがヒトの複雑な形質や疾患と関連付けられてきたが、それらの大半はノンコーディングDNA上にあるために、その生物学的機能の解明はいまだに困難である。今回我々は、SNP-SELEX（single-nucleotide polymorphism evaluation by systematic evolution of ligands ...

Scientists have uncovered new genetic causes of diabetes in infants, pointing to a region of the genome that has long been ...

De novo gene evolution describes the process by which entirely new genes originate from previously non-coding DNA rather than from the duplication and divergence of existing genetic material. This ...

When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a ...

細胞の性分化を阻止する長鎖ノンコーディングRNAを発見 細胞内で機能を持つノンコーディングRNAを探し出す方法の開発と実践 ＜発表のポイント＞ 細胞研究は従来、DNAや酵素などのタンパク質に着目されてきたが、近年、「ジャンク」とされていた一部の ...