The author describes the scientific foundations and implications of the results of a randomized, controlled trial of Mim8, a new mimetic of factor VIIIa, to treat hemophilia A.

A 76-year-old woman, who had a history of treated hepatitis C virus infection, presented with rapidly progressive kidney failure and a stroke. Palpable purpura on the legs was noted. A diagnosis ...

Marston et al. (Jan. 29 issue)1 report that treatment with olezarsen in patients with severe hypertriglyceridemia substantially lowered triglyceride levels and was associated with ...

Guidelines recommend a trial of antiarrhythmic drugs before catheter ablation for persistent atrial fibrillation. Whether pulsed field ablation (PFA) may be a preferred initial treatment is ...

Blood-pressure reduction is the only proven treatment to prevent stroke. Whether a single pill that combines three ...

There has been substantial interest in the development of GLP-1 drugs and optimism about their public health effects. But some worrisome signals related to disordered eating have emerged.

The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But ...

Whether treatment with balanced crystalloid fluid leads to better outcomes than 0.9% saline in children treated for septic ...

Post-thrombotic syndrome is common after deep-vein thrombosis and can cause severe symptoms involving the limbs that impair patients’ activity and quality of life. Endovascular therapy can ...

A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney ...

A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during fever. Laboratory tests showed an elevated ESR and elevated ...

It is regrettable that pulmonary embolism as a discrete cause of sudden cardiac arrest in athletes is not addressed by Lampert and Harmon’s recent review (Jan. 15 issue).1 In an ...